External beam irradiation and the combination of cisplatin and carmustine followed by carmustine alone for the treatment of high-grade glioma: a phase 2 Southwest Oncology Group trial.

Publication Type:

Journal Article


Cancer, Volume 113, Issue 3, p.559-65 (2008)


2008, Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Carmustine, Cisplatin, Combined Modality Therapy, Female, Glioma, Humans, Male, Middle Aged, Neoplasm Staging, Public Health Sciences Division, Radiotherapy, Conformal, Southwestern United States, Survival Analysis, Treatment Outcome


The poor prognosis reported for patients with high-grade glial neoplasms indicates a need for the development of multimodality therapeutic approaches. The addition of chemotherapy has contributed variably to increased survival. The objective of the current study (Southwest Oncology Group [SWOG] 9016) was to determine whether concurrent radiotherapy and chemotherapy with the combination of carmustine and cisplatin could be given safely in a cooperative group setting. Additional objectives included the estimation of response rate, the rate of disease stabilization, and the probability of 1-year survival.