Extended B(*)73 Haplotypes Confirmed by Family Studies.

Publication Type:

Journal Article

Source:

Human immunology, Volume 74, p.155-155 (2013)

ISBN:

0198-8859

Keywords:

2013, Clinical Research Division, December 2013, Immunology

Abstract:

Aim: The B*73:01 allele has been a subject of interest since the mid-1990's, when it was recognized as defining its own lineage, separate from all other HLA-B alleles (Parham et al). Recently, B*73 has been implicated in the evolution of the Denisovans, an archaic human group, despite the fact that it has not yet been found in a Denisovan specimen (Abi-Rached et al). The theory that B*73 haplotypes were acquired by introgression from Denisovans prompted us to search our current clinical database for extended B*73 haplotypes, as demonstrated by family studies. Methods: We searched our clinical database for any patients or family members that had been typed as B*73 and looked for extended haplotypes which were confirmed within each family. Results: From January 2000 to February 2013, a total of 10 families were identified with extended B*73 haplotypes (Table 1). Four families had the haplotype A*02:01, C*15:05, B*73:01, DRB1*04:05, DQB1*02:02. The six remaining families had unique extended haplotypes. C*15:05 was present in every haplotype.(Table 1) Conclusions: Despite the diversity of the B*73 haplotypes, in every case B*73:01 was in strong linkage disequilibrium with C*15:05. This was expected, because it has been estimated that worldwide,  98% of people carrying B*73 also carry C*15:05 (Abi-Rached et al). The only Denisovan individual who has been HLA typed was C*15:05:02, C*12:02:02, but lacked a B*73:01 allele and was typed as B*15:58, B*35:63. It will be interesting to see if Class II typing for this archaic sample corresponds to any of the Class II alleles in the extended haplotypes in this study.

Notes:

PT: J; CT: 39th Annual Meeting of the American-Society-for-Histocompatibility-and-Immunogenetics (ASHI); CY: NOV 17-21, 2013; CL: Chicago, IL; SP: Amer Soc Histocompatibil & Immunogenet; NR: 0; TC: 0; J9: HUM IMMUNOL; SU: S; PG: 1; GA: 239YC