The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells.

Publication Type:

Journal Article


The Prostate, Volume 70, Issue 4, p.412-24 (2010)


2010, Animals, Bone Neoplasms, Calcification, Physiologic, Cell Line, Tumor, Center-Authored Paper, Culture Media, Conditioned, Fluorescent Antibody Technique, Direct, gene expression, Gene Expression Profiling, Genomics Core Facility, Human Biology Division, Humans, Macrophages, Male, MICE, Mice, SCID, Oligonucleotide Array Sequence Analysis, Osteoblasts, Osteoclasts, Osteolysis, Prostatic Neoplasms, Public Health Sciences Division, Shared Resources, Tibia, Tissue Array Analysis, Xenograft Model Antitumor Assays


Prostate cancer (PCa) has a propensity to metastasize to bone. Tumor cells replace bone marrow and can elicit an osteoblastic, osteolytic, or mixed bone response. Our objective was to elucidate the mechanisms and key factors involved in promoting osteoclastogenesis in PCa bone metastasis.