Expression of cell cycle-regulated genes and prostate cancer prognosis in a population-based cohort.

Publication Type:

Journal Article

Authors:

Rubicz, Rohina; Zhao, Shanshan; April, Craig; Wright, Jonathan L; Kolb, Suzanne; Coleman, Ilsa; Lin, Daniel W; Nelson, Peter S; Ostrander, Elaine A; Feng, Ziding; Fan, Jian-Bing; Stanford, Janet L

Source:

The Prostate (2015)

Abstract:

Prostate cancer (PCa) is clinically and biologically heterogeneous, making it difficult to predict at detection whether it will take an indolent or aggressive disease course. Cell cycle-regulated genes may be more highly expressed in actively dividing cells, with transcript levels reflecting tumor growth rate. Here, we evaluated expression of cell cycle genes in relation to PCa outcomes in a population-based cohort.