Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction.

Publication Type:

Journal Article

Source:

Critical care (London, England), Volume 19, Issue 1, p.225 (2015)

Abstract:

The Tie-2/angiopoietin (Tie-2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenesis of sepsis-related microvascular leak and multiple organ dysfunction syndrome (MODS). Mechanisms responsible for dysregulation of angiogenic genes in sepsis are poorly defined.