Evidence for limited genetic compartmentalization of HIV-1 between lung and blood.

Publication Type:

Journal Article

Authors:

Heath, Laura; Fox, Alan; McClure, Jan; Diem, Kurt; van 't Wout, Angélique B; Zhao, Hong; Park, David R; Schouten, Jeffrey T; Twigg, Homer L; Corey, Lawrence; Mullins, James I; Mittler, John E

Source:

PloS one, Volume 4, Issue 9, p.e6949 (2009)

Keywords:

2009, BRONCHOALVEOLAR LAVAGE, Center-Authored Paper, Clinical Research Division, Genetic Variation, Genotype, GLYCOSYLATION, HIV Infections, HIV-1, Humans, Leukocytes, Mononuclear, lung, Models, Statistical, Phylogeny, Polymerase Chain Reaction, RNA, Sequence Analysis, DNA, T-Lymphocytes, Vaccine and Infectious Disease Institute

Abstract:

HIV-1 is frequently detected in the lungs of infected individuals and is likely important in the development of pulmonary opportunistic infections. The unique environment of the lung, rich in alveolar macrophages and with specialized local immune responses, may contribute to differential evolution or selection of HIV-1.