Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 15, Issue 9, p.3223-30 (2009)

Keywords:

2009, Aged, Case-Control Studies, Center-Authored Paper, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8, Cohort Studies, Genetic Predisposition to Disease, Genotype, Humans, Incidence, Male, Middle Aged, Neoplasm Staging, Polymorphism, Single Nucleotide, Prospective Studies, Prostatic Neoplasms, Public Health Sciences Division, Risk Factors, Survival Rate

Abstract:

Variants at chromosomal loci 8q24 and 17q are established risk factors for prostate cancer. Many studies have confirmed the findings for risk, but few have examined aggressiveness and other clinical variables in detail. Additionally, Gleason score is typically used as a surrogate for the primary end point of prostate cancer mortality. We investigated whether the 8q24 and 17q risk variants are associated with clinical variables as well as prostate cancer mortality.