Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Publication Type:

Journal Article

Authors:

Lee, Alice W; Tyrer, Jonathan P; Doherty, Jennifer A; Stram, Douglas A; Kupryjanczyk, Jolanta; Dansonka-Mieszkowska, Agnieszka; Plisiecka-Halasa, Joanna; Spiewankiewicz, Beata; Myers, Emily J; Chenevix-Trench, Georgia; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Hein, Alexander; Vergote, Ignace; Van Nieuwenhuysen, Els; Lambrechts, Diether; Wicklund, Kristine G; Eilber, Ursula; Wang-Gohrke, Shan; Chang-Claude, Jenny; Rudolph, Anja; Sucheston-Campbell, Lara; Odunsi, Kunle; Moysich, Kirsten B; Shvetsov, Yurii B; Thompson, Pamela J; Goodman, Marc T; Wilkens, Lynne R; Dörk, Thilo; Hillemanns, Peter; Dürst, Matthias; Runnebaum, Ingo B; Bogdanova, Natalia; Pelttari, Liisa M; Nevanlinna, Heli; Leminen, Arto; Edwards, Robert P; Kelley, Joseph L; Harter, Philipp; Schwaab, Ira; Heitz, Florian; du Bois, Andreas; Orsulic, Sandra; Lester, Jenny; Walsh, Christine; Karlan, Beth Y; Hogdall, Estrid; Kjaer, Susanne K; Jensen, Allan; Vierkant, Robert A; Cunningham, Julie M; Goode, Ellen L; Fridley, Brooke L; Southey, Melissa C; Giles, Graham G; Bruinsma, Fiona; Wu, Xifeng; Hildebrandt, Michelle A T; Lu, Karen; Liang, Dong; Bisogna, Maria; Levine, Douglas A; Weber, Rachel Palmieri; Schildkraut, Joellen M; Iversen, Edwin S; Berchuck, Andrew; Terry, Kathryn L; Cramer, Daniel W; Tworoger, Shelley S; Poole, Elizabeth M; Olson, Sara H; Orlow, Irene; Bandera, Elisa V; Bjorge, Line; Tangen, Ingvild L; Salvesen, Helga B; Krakstad, Camilla; Massuger, Leon F A G; Kiemeney, Lambertus A; Aben, Katja K H; van Altena, Anne M; Bean, Yukie; Pejovic, Tanja; Kellar, Melissa; Le, Nhu D; Cook, Linda S; Kelemen, Linda E; Brooks-Wilson, Angela; Lubinski, Jan; Gronwald, Jacek; Cybulski, Cezary; Jakubowska, Anna; Wentzensen, Nicolas; Brinton, Louise A; Lissowska, Jolanta; Yang, Hannah; Nedergaard, Lotte; Lundvall, Lene; Hogdall, Claus; Song, Honglin; Campbell, Ian G; Eccles, Diana; Glasspool, Rosalind; Siddiqui, Nadeem; Carty, Karen; Paul, James; McNeish, Iain A; Sieh, Weiva; McGuire, Valerie; Rothstein, Joseph H; Whittemore, Alice S; McLaughlin, John R; Risch, Harvey A; Phelan, Catherine M; Anton-Culver, Hoda; Ziogas, Argyrios; Menon, Usha; Ramus, Susan J; Gentry-Maharaj, Aleksandra; Harrington, Patricia; Pike, Malcolm C; Modugno, Francesmary; Rossing, Mary Anne; Ness, Roberta B; Pharoah, Paul D P; Stram, Daniel O; Wu, Anna H; Pearce, Celeste Leigh

Source:

Gynecologic oncology, Volume 136, Issue 3, p.542-8 (2015)

Abstract:

Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted.