Evaluating immune correlates in HIV type 1 vaccine efficacy trials: what RV144 may provide.

Publication Type:

Journal Article

Authors:

Rolland, Morgane; Gilbert, Peter

Source:

AIDS research and human retroviruses, Volume 28, Issue 4, p.400-4 (2012)

Keywords:

2012, May 2012, Vaccine and Infectious Disease Division

Abstract:

Abstract Since the RV144 vaccine combination showed efficacy in a Phase III trial, it provides an opportunity to generate hypotheses about the immune responses necessary for protection against HIV-1 infection, and these results could help devise vaccine candidates with higher efficacy. Here we describe how researchers can determine the correlates of immune protection for an HIV/AIDS vaccine, particularly in the context of the RV144 trial, and we discuss the terminology used to describe correlates and surrogates.