Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk.

Publication Type:

Journal Article


PloS one, Volume 5, Issue 9, p.e12598 (2010)


2010, Africa, Eastern, Africa, Southern, Anti-HIV Agents, Center-Authored Paper, Cohort Studies, Female, Follow-Up Studies, Heterosexuality, HIV Infections, HIV-1, Humans, Male, Risk Factors, RNA, Viral, Sexual Partners, Vaccine and Infectious Disease Division, Viral Load


The risk of sexual transmission of HIV-1 is strongly associated with the level of HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 prevention interventions. A quantitative understanding of the relationship of plasma HIV-1 RNA and HIV-1 transmission risk could help predict the impact of candidate HIV-1 prevention interventions that operate by reducing plasma HIV-1 levels, such as antiretroviral therapy (ART), therapeutic vaccines, and other non-ART interventions.