Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections.

Publication Type:

Journal Article


The Journal of infectious diseases, Volume 204, Issue 2, p.323-6 (2011)


2011, Administration, Oral, Adolescent, Adult, Anti-Infective Agents, Bacteria, Candida, Candidiasis, Vulvovaginal, Chemoprevention, Female, Humans, Middle Aged, Placebos, Treatment Outcome, Trichomonas, Trichomonas Vaginitis, Vaccine and Infectious Disease Division, Vagina, Vaginal Diseases, Vaginosis, Bacterial, Young Adult


Data from a randomized trial of oral periodic presumptive treatment (PPT) to reduce vaginal infections were analyzed to assess the effect of the intervention on a healthy vaginal environment (normal flora confirmed by Gram stain with no candidiasis or trichomoniasis). The incidence of a healthy vaginal environment was 608 cases per 100 person-years in the intervention arm and 454 cases per 100 person-years in the placebo arm (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.17-1.58). Sustained vaginal health (healthy vaginal environment for ≥3 consecutive visits) was also more frequent in the intervention arm (HR, 1.69; 95% CI, 1.23-2.33). PPT is effective at establishing and sustaining a healthy vaginal environment.