Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 204, Issue 2, p.323-6 (2011)

Keywords:

2011, Administration, Oral, Adolescent, Adult, Anti-Infective Agents, Bacteria, Candida, Candidiasis, Vulvovaginal, Chemoprevention, Female, Humans, Middle Aged, Placebos, Treatment Outcome, Trichomonas, Trichomonas Vaginitis, Vaccine and Infectious Disease Division, Vagina, Vaginal Diseases, Vaginosis, Bacterial, Young Adult

Abstract:

Data from a randomized trial of oral periodic presumptive treatment (PPT) to reduce vaginal infections were analyzed to assess the effect of the intervention on a healthy vaginal environment (normal flora confirmed by Gram stain with no candidiasis or trichomoniasis). The incidence of a healthy vaginal environment was 608 cases per 100 person-years in the intervention arm and 454 cases per 100 person-years in the placebo arm (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.17-1.58). Sustained vaginal health (healthy vaginal environment for ≥3 consecutive visits) was also more frequent in the intervention arm (HR, 1.69; 95% CI, 1.23-2.33). PPT is effective at establishing and sustaining a healthy vaginal environment.