Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia.

Publication Type:

Journal Article

Authors:

Estey, E H

Source:

Leukemia, Volume 27, Issue 9, p.1803-12 (2013)

Keywords:

2013, Antimetabolites, Antineoplastic, Antineoplastic Combined Chemotherapy Protocols, Azacitidine, Clinical Research Division, DNA Methylation, DNA Modification Methylases, Enzyme Inhibitors, Epigenesis, Genetic, hematopoietic stem cell transplantation, Humans, Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, October 2013, Prognosis, Remission Induction, Treatment Outcome

Abstract:

Randomized trials have clearly demonstrated that the hypomethylating agents azacitidine and decitabine are more effective than 'best supportive care'(BSC) in reducing transfusion frequency in 'low-risk' myelodysplasia (MDS) and in prolonging survival compared with BSC or low-dose ara-C in 'high-risk' MDS or acute myeloid leukemia (AML) with 21-30% blasts. They also appear equivalent to conventional induction chemotherapy in AML with >20% blasts and as conditioning regimens before allogeneic transplant (hematopoietic cell transplant, HCT) in MDS. Although azacitidine or decitabine are thus the standard to which newer therapies should be compared, here we discuss whether the improvement they afford in overall survival is sufficient to warrant a designation as a standard in treating individual patients. We also discuss pre- and post-treatment covariates, including assays of methylation to predict response, different schedules of administration, combinations with other active agents and use in settings other than active disease, in particular post HCT. We note that rational development of this class of drugs awaits delineation of how much of their undoubted effect in fact results from hypomethylation and reactivation of gene expression.