On emerging nuclear order.

Publication Type:

Journal Article

Source:

The Journal of cell biology, Volume 192, Issue 5, p.711-21 (2011)

Keywords:

2011, Animals, Basic Sciences Division, Cell Nucleus, Center-Authored Paper, Chromatin Assembly and Disassembly, CHROMOSOMES, Gene Expression Regulation, Gene Regulatory Networks, Humans, Interphase, Intranuclear Space, Models, Genetic, Neoplasms, Public Health Sciences Division, Translocation, Genetic

Abstract:

Although the nonrandom nature of interphase chromosome arrangement is widely accepted, how nuclear organization relates to genomic function remains unclear. Nuclear subcompartments may play a role by offering rich microenvironments that regulate chromatin state and ensure optimal transcriptional efficiency. Technological advances now provide genome-wide and four-dimensional analyses, permitting global characterizations of nuclear order. These approaches will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease.