Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons.

Publication Type:

Journal Article

Source:

Open forum infectious diseases, Volume 4, Issue 2, p.ofx055 (2017)

Abstract:

Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the "nil" value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.