Efficacy dilution in randomized placebo-controlled vaginal microbicide trials.

Publication Type:

Journal Article

Source:

Emerging themes in epidemiology, Volume 6, p.5 (2009)

Keywords:

2009, Vaccine and Infectious Disease Institute

Abstract:

To date different vaginal gel microbicides have been evaluated in phase 2b/3 trials, but none have demonstrated effectiveness for preventing HIV infection. Failure to demonstrate effectiveness however does not necessarily indicate that a product is truly inefficacious, as several sources of efficacy dilution may compromise our ability to identify products that may have been truly efficacious.