The effects of aging on the molecular and cellular composition of the prostate microenvironment.

Publication Type:

Journal Article


PloS one, Volume 5, Issue 9 (2010)


2010, Aging, Animals, Center-Authored Paper, Comparative Medicine Core Facility, Experimental Histopathology Core Facility, gene expression, Genomics Core Facility, Human Biology Division, Male, MICE, Mice, Inbred C57BL, prostate, Scientific Imaging Core Facility, Shared Resources, Stromal Cells, Time Factors


Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate gland including benign prostatic hyperplasia (BPH) and prostate carcinoma. The prostate is comprised of a functional secretory epithelium, a basal epithelium, and a supporting stroma comprised of structural elements, and a spectrum of cell types that includes smooth muscle cells, fibroblasts, and inflammatory cells. As reciprocal interactions between epithelium and stromal constituents are essential for normal organogenesis and serve to maintain normal functions, discordance within the stroma could permit or promote disease processes. In this study we sought to identify aging-associated alterations in the mouse prostate microenvironment that could influence pathology.