Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials.

Publication Type:

Journal Article

Source:

Menopause (New York, N.Y.), Volume 18, Issue 1, p.44-52 (2011)

Keywords:

2011, Absorptiometry, Photon, Accidental Falls, Adiposity, Aged, Aging, Body Weights and Measures, Bone Density, Double-Blind Method, Estrogen Replacement Therapy, Estrogens, Female, Fractures, Bone, Humans, Longitudinal Studies, Middle Aged, Muscle, Skeletal, Postmenopause, Progestins, Proportional Hazards Models, Public Health Sciences Division, Time Factors

Abstract:

Loss of lean body mass with aging may contribute to falls and fractures. The objective of this analysis was to determine if taking postmenopausal hormone therapy (or HT: estrogen plus progestogen therapy or estrogen therapy alone) favorably affects age-related changes in lean body mass and if these changes partially account for decreased falls or fractures with HT.