Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials.

Publication Type:

Journal Article


Menopause (New York, N.Y.), Volume 18, Issue 1, p.44-52 (2011)


2011, Absorptiometry, Photon, Accidental Falls, Adiposity, Aged, Aging, Body Weights and Measures, Bone Density, Double-Blind Method, Estrogen Replacement Therapy, Estrogens, Female, Fractures, Bone, Humans, Longitudinal Studies, Middle Aged, Muscle, Skeletal, Postmenopause, Progestins, Proportional Hazards Models, Public Health Sciences Division, Time Factors


Loss of lean body mass with aging may contribute to falls and fractures. The objective of this analysis was to determine if taking postmenopausal hormone therapy (or HT: estrogen plus progestogen therapy or estrogen therapy alone) favorably affects age-related changes in lean body mass and if these changes partially account for decreased falls or fractures with HT.