Effect of Fish Oil on Monoepoxides Derived from Fatty Acids during Cardiac Surgery.

Publication Type:

Journal Article


Journal of lipid research (2016)


Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P<0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P≤0.004). n-3 PUFA supplementation did not significantly alter n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at post-op day-2 (p<0.001). Conclusions Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in post-operative n-3 MEFAs, but not n-6 MEFAs; and levels of increase related to circulating n-3 PUFA precursors.