Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis.

Publication Type:

Journal Article

Source:

Blood, Volume 127, Issue 20, p.2427-2438 (2016)

Abstract:

Single-center studies have reported an association between early (before day 100) cytomegalovirus (CMV) reactivation and decreased incidence of relapse for acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation (HCT). To substantiate these preliminary findings, the Center for International Blood and Marrow Transplant Research (CIBMTR) Database was interrogated to analyze the impact of CMV reactivation on hematologic disease relapse in the current era. Data from 9,469 patients transplanted with bone marrow or peripheral blood between 2003 and 2010 were analyzed according to four disease categories: acute myeloid leukemia (AML, n=5,310); acute lymphoblastic leukemia (ALL, n=1,883); chronic myeloid leukemia (CML, n=1,079); and myelodysplastic syndrome (MDS, n=1,197). Median time to initial CMV reactivation was 41 days (range, 1 to 362 days). CMV reactivation had no preventive effect on hematologic disease relapse irrespective of diagnosis. Moreover, CMV reactivation was associated with higher non-relapse mortality [relative risk (RR) among disease categories ranged from 1.61 to 1.95 and p values from 0.0002 to <0.0001, 95% CI (1.14 - 2.61]. As a result, CMV reactivation was associated with lower overall survival (OS) for AML (RR=1.27, 95% CI 1.17-1.38, p<0.0001), ALL (RR=1.46, 95% CI 1.25-1.71, p<0.0001), CML (RR=1.49, 95% CI 1.19-1.88, p=0.0005), and MDS (RR=1.31, 95% CI 1.09-1.57, p=0.003). In conclusion, CMV reactivation continues to remain a risk factor for poor post-transplant outcomes and does not seem to confer protection against hematologic disease relapse.