Dynamics and control of state-dependent networks for probing genomic organization.

Publication Type:

Journal Article

Source:

Proceedings of the National Academy of Sciences of the United States of America, Volume 108, Issue 42, p.17257-62 (2011)

Keywords:

2011, Animals, Basic Sciences Division, Cell Differentiation, Center-Authored Paper, Feedback, Physiological, GATA1 Transcription Factor, Gene Regulatory Networks, Genomics Core Facility, Hematopoiesis, Humans, Models, Biological, Models, Genetic, MyoD Protein, October 2011, Public Health Sciences Division, Scientific Imaging Core Facility, Shared Resources

Abstract:

A state-dependent dynamic network is a collection of elements that interact through a network, whose geometry evolves as the state of the elements changes over time. The genome is an intriguing example of a state-dependent network, where chromosomal geometry directly relates to genomic activity, which in turn strongly correlates with geometry. Here we examine various aspects of a genomic state-dependent dynamic network. In particular, we elaborate on one of the important ramifications of viewing genomic networks as being state-dependent, namely, their controllability during processes of genomic reorganization such as in cell differentiation.