DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements.

Publication Type:

Journal Article


Epigenetics & chromatin, Volume 8, p.8 (2015)


Comparative Medicine Core Facility


The brain, spinal cord, and neural retina comprise the central nervous system (CNS) of vertebrates. Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is a significant challenge. Whole-genome mapping of DNase I-hypersensitive sites (DHSs) has been used to identify cis-regulatory elements in many tissues. We have applied this approach to the mouse CNS, including developing and mature neural retina, whole brain, and two well-characterized brain regions, the cerebellum and the cerebral cortex.