DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements.

Publication Type:

Journal Article

Source:

Epigenetics & chromatin, Volume 8, p.8 (2015)

Keywords:

Comparative Medicine Core Facility

Abstract:

The brain, spinal cord, and neural retina comprise the central nervous system (CNS) of vertebrates. Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is a significant challenge. Whole-genome mapping of DNase I-hypersensitive sites (DHSs) has been used to identify cis-regulatory elements in many tissues. We have applied this approach to the mouse CNS, including developing and mature neural retina, whole brain, and two well-characterized brain regions, the cerebellum and the cerebral cortex.