DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia.

Publication Type:

Journal Article

Source:

PloS one, Volume 7, Issue 11, p.e50533 (2012)

Keywords:

2012, Center-Authored Paper, Clinical Research Division, Genomics Core Facility, January 2013, Shared Resources

Abstract:

Changes in host tumor genome DNA methylation patterns are among the molecular alterations associated with HPV-related carcinogenesis. However, there is little known about the epigenetic changes associated specifically with the development of anal squamous cell cancer (SCC). We sought to characterize broad methylation profiles across the spectrum of anal squamous neoplasia.