DNA hypermethylation, Her-2/neu overexpression and p53 mutations in ovarian carcinoma.

Publication Type:

Journal Article


Gynecologic oncology, Volume 111, Issue 2, p.320-9 (2008)


2008, Adult, Center-Authored Paper, DNA Methylation, DNA, Neoplasm, Experimental Histopathology Core Facility, Female, Genes, erbB-2, Genes, p53, Humans, Immunohistochemistry, Middle Aged, Mutation, Neoplasm Staging, Ovarian Neoplasms, Polymerase Chain Reaction, Public Health Sciences Division, Receptor, erbB-2, Shared Resources, Tumor Suppressor Protein p53


To define patterns of aberrant DNA methylation, p53 mutation and Her-2/neu overexpression in tissues from benign (n=29), malignant (n=100), and border line malignant ovaries (n=10), as compared to normal (n=68) ovarian tissues. Further, to explore the relationship between the presence of genetic and epigenetic abnormalities in ovarian cancers, and assess the association between epigenetic changes and clinical stage of malignancy at presentation and response to therapy.