Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

Publication Type:

Journal Article

Source:

Developmental biology, Volume 377, Issue 2, p.375-384 (2013)

Keywords:

2013, Center-Authored Paper, Comp Med Small Animal, Comparative Medicine Core Facility, Flow Cytometry Core Facility, Genomics Core Facility, Human Biology Division, March 2013, Scientific Imaging Core Facility

Abstract:

Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells.