Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

Publication Type:

Journal Article


Developmental biology, Volume 377, Issue 2, p.375-384 (2013)


2013, Center-Authored Paper, Comp Med Small Animal, Comparative Medicine Core Facility, Flow Cytometry Core Facility, Genomics Core Facility, Human Biology Division, March 2013, Scientific Imaging Core Facility


Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells.