Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.

Publication Type:

Journal Article


BMC evolutionary biology, Volume 10, p.223 (2010)


2010, Amino Acid Sequence, Animals, Basic Sciences Division, Center-Authored Paper, Evolution, Molecular, Genetic Variation, Humans, Interleukin-4, Likelihood Functions, MAMMALS, MICE, Mice, Inbred BALB C, Molecular Sequence Data, Phylogeny, Protein Binding, Protein Structure, Secondary, Receptors, Interleukin-4, Selection, Genetic, Sequence Alignment, Sequence Analysis, DNA, Species Specificity


Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths 1. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we explored mammalian IL4 evolution.