Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial.

Publication Type:

Journal Article


The Journal of clinical endocrinology and metabolism, Volume 96, Issue 2, p.430-7 (2011)


2011, Adult, androgens, Cell Proliferation, Clinical Research Division, DIHYDROTESTOSTERONE, Double-Blind Method, Endpoint Determination, Epithelial Cells, Human Biology Division, Humans, Immunohistochemistry, In Situ Hybridization, Ki-67 Antigen, Male, microdissection, Middle Aged, prostate, Prostate-Specific Antigen


Concern exists that androgen treatment might adversely impact prostate health in older men. Dihydrotestosterone (DHT), derived from local conversion of testosterone to DHT by 5α-reductase enzymes, is the principal androgen within the prostate. Exogenous androgens raise serum DHT concentrations, but their effects on the prostate are not clear.