Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 16, Issue 22, p.5414-23 (2010)

Keywords:

2010, Aged, Center-Authored Paper, DISEASE PROGRESSION, EPITHELIUM, Gene Expression Profiling, Genomics Core Facility, Human Biology Division, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Prostatic Neoplasms, Public Health Sciences Division, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Shared Resources, Specimen Processing Core Facility, static Neoplasms, Trans-Activators Human Biology Division

Abstract:

Several malignancies are known to exhibit a "field effect," whereby regions beyond tumor boundaries harbor histologic or molecular changes that are associated with cancer. We sought to determine if histologically benign prostate epithelium collected from men with prostate cancer exhibits features indicative of premalignancy or field effect.