Differential expression of the alpha2 chain of the interleukin-13 receptor in metastatic human prostate cancer ARCaPM cells.

Publication Type:

Journal Article

Source:

The Prostate, Volume 70, Issue 9, p.993-1001 (2010)

Keywords:

2010, Animals, Blotting, Western, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Center-Authored Paper, Gene Expression Regulation, Neoplastic, Genomics Core Facility, Human Biology Division, Humans, Immunohistochemistry, Interleukin-13, Interleukin-13 Receptor alpha2 Subunit, Male, MICE, Mice, Nude, prostate, Reverse Transcriptase Polymerase Chain Reaction, Shared Resources, Transfection, Transplantation, Heterologous

Abstract:

The alpha2 chain of the interleukin-13 receptor (IL13Ralpha2) is a high-affinity receptor and a candidate target for cytotoxic killing of cancer cells. Availability of a human prostate cancer cell line with high level of IL13Ralpha2 expression will facilitate the development of therapeutic modalities.