Differential engraftment of genetically modified CD34(+) and CD34(-) hematopoietic cell subsets in lethally irradiated baboons.

Publication Type:

Journal Article

Source:

Experimental hematology, Volume 28, Issue 5, p.508-18 (2000)

Keywords:

Animals, Antigens, CD34, B-Lymphocytes, Bone Marrow Cells, Cells, Cultured, Clinical Research Division, Coculture Techniques, Colony-Forming Units Assay, Female, Gene Transfer Techniques, Genetic Vectors, Growth Substances, hematopoietic stem cell transplantation, Hematopoietic Stem Cells, Kanamycin Kinase, Leukemia Virus, Gibbon Ape, Male, Papio, T-Lymphocytes, Transplantation, Homologous, Whole-Body Irradiation

Abstract:

To test gibbon ape leukemia virus (GALV) pseudotype vector transduction of marrow subpopulations that contribute to hematopoietic reconstitution in vivo.