Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression from Adenoma to Colorectal Cancer.

Publication Type:

Journal Article

Source:

Gastroenterology, Volume 147, Issue 2, p.418-29.e8 (2014)

Keywords:

2014, Center-Authored Paper, Clinical Research Division, Experimental Histopathology Core Facility, Genomics Core Facility, May 2014, Public Health Sciences Division

Abstract:

& Aims: Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenetic and genetic alterations have been detected in conventional tubular adenomas, little is known about how these affect progression to CRC. We compared methylomes of normal colon mucosa, tubular adenomas, and colorectal cancers to determine how epigenetic alterations might contribute to cancer formation.