Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins.

Publication Type:

Journal Article


Developmental dynamics : an official publication of the American Association of Anatomists, Volume 241, Issue 3, p.608-26 (2012)


2012, Antibody Development Core Facility, Apr 2012, April 2012, Basic Sciences Division, Center-Authored Paper, Scientific Imaging Core Facility, Shared Resources


Wiskott-Aldrich Syndrome (WASP) family proteins participate in many cellular processes involving rearrangements of the actin cytoskeleton. To the date, four WASP subfamily members have been described in Drosophila: Wash, WASp, SCAR, and Whamy. Wash, WASp, and SCAR are essential during early Drosophila development where they function in orchestrating cytoplasmic events including membrane-cytoskeleton interactions. A mutant for Whamy has not yet been reported.