Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States.

Publication Type:

Journal Article

Source:

Breast cancer research and treatment, Volume 116, Issue 3, p.587-94 (2009)

Keywords:

2009, Adult, Breast, Breast Neoplasms, Center-Authored Paper, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyestrones, Isoflavones, Mammography, Middle Aged, Nutrition Assessment Core Facility, PHENOTYPE, Phytoestrogens, Public Health Sciences Division, Shared Resources, Soy Foods, Specimen Processing Core Facility

Abstract:

Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between the capacity to produce these metabolites and breast density.