Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States.

Publication Type:

Journal Article


Breast cancer research and treatment, Volume 116, Issue 3, p.587-94 (2009)


2009, Adult, Breast, Breast Neoplasms, Center-Authored Paper, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyestrones, Isoflavones, Mammography, Middle Aged, Nutrition Assessment Core Facility, PHENOTYPE, Phytoestrogens, Public Health Sciences Division, Shared Resources, Soy Foods, Specimen Processing Core Facility


Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between the capacity to produce these metabolites and breast density.