Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Single Nucleotide Polymorphisms Are Not Associated with Outcomes after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis.

Publication Type:

Journal Article

Source:

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (2014)

Keywords:

2014, April 2014, Clinical Research Division

Abstract:

Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) plays an essential role in T cell homeostasis by restraining immune responses. AG and GG genotypes of donor CTLA-4 SNP rs4553808 in patients after unrelated donor (URD) hematopoietic stem cell transplants (HSCT) have been shown to be an independent predictor of inferior relapse free survival (RFS) and overall survival (OS) compared to the AA genotype in single center studies. We tested the hypothesis that SNP rs4553808 is associated with RFS, OS, non-relapse mortality (NRM) and the cumulative incidence of acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD) in adults with acute myeloid leukemia (AML) and advanced myelodysplastic syndrome (MDS) undergoing a first 8/8 or 7/8 HLA matched URD HSCT. Multivariable analysis adjusting for relevant donor and recipient characteristics showed no significant association between SNP rs4553808 and OS, RFS, NRM, and incidence of aGVHD and cGVHD. An exploratory analysis of other CTLA-4 SNPs as well as studying the interaction with ATG also demonstrated no significant associations. Our results indicate that CTLA-4 SNPs are not associated with HSCT outcomes.