Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Publication Type:

Journal Article

Source:

The Journal of nutrition, Volume 144, Issue 11, p.1850-7 (2014)

Keywords:

2014, Adult, Biological Markers, Brassicaceae, Center-Authored Paper, Consortium Authored Paper, Cross-Over Studies, diet, Female, Gene Expression Regulation, Glutathione Transferase, Humans, INFLAMMATION, Male, Nutrition Assessment Core Facility, Prevention Center Core Facility, Public Health Sciences Division, Shared Resources, Specimen Processing Core Facility, Vegetables, Young Adult

Abstract:

Isothiocyanates in cruciferous vegetables modulate signaling pathways critical to carcinogenesis, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of inflammation. Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.