Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.

Publication Type:

Journal Article


Nutrition journal, Volume 10, p.11 (2011)


2011, Adult, Blood Proteins, Brassicaceae, Center-Authored Paper, Cross-Over Studies, diet, Female, Genotype, Glutathione Transferase, Humans, Isothiocyanates, Linear Models, Male, Peptides, Prealbumin, Prevention Center Core Facility, Proteomics Core Facility, Public Health Sciences Division, Risk Factors, Shared Resources, Specimen Processing Core Facility, Vegetables, Young Adult


Cruciferous vegetable intake is inversely associated with the risk of several cancers. Isothiocyanates (ITC) are hypothesized to be the major bioactive constituents contributing to these cancer-preventive effects. The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo.