The CRC screening process in community settings: A conceptual model for the Population-based Research Optimizing Screening through Personalized Regimens Consortium.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2014)


2014, July 2014, Public Health Sciences Division


Reducing colorectal cancer (CRC) mortality by promoting screening has been a national goal for two decades. The National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium is the first federal initiative to foster coordinated, transdisciplinary research evaluating the entire cancer screening process in community settings. PROSPR is creating a central data repository to facilitate research evaluating the breast, cervical, and CRC screening process across different patient populations, provider types, and delivery systems. Data are being collected and organized at the multiple levels in which individuals are nested (e.g., healthcare systems, facilities, providers, patients). Here, we describe a conceptual model of the CRC screening process guiding data collection and highlight critical research questions that will be addressed through pooled data. We also describe the three Research Centers focused on CRC screening with respect to study populations, practice settings, and screening policies. PROSPR comprehensively elucidates the complex screening process through observational study, and has potential to improve care delivery beyond the healthcare systems studied. Findings will inform intervention designs and policies to optimize CRC screening delivery and advance the Institute of Medicine's goals of effective, efficient, coordinated, timely, and safe health care with respect to evidence-based cancer screening.