Cost-effectiveness of pre-exposure prophylaxis targeted to high-risk serodiscordant couples as a bridge to sustained ART use in Kampala, Uganda.

Publication Type:

Journal Article

Authors:

Ying, Roger; Sharma, Monisha; Heffron, Renee; Celum, Connie L; Baeten, Jared M; Katabira, Elly; Bulya, Nulu; Barnabas, Ruanne V

Source:

Journal of the International AIDS Society, Volume 18, Issue 4 Suppl 3, p.20013 (2015)

Abstract:

Despite scale-up of antiretroviral therapy (ART) for treating HIV-positive persons, HIV incidence remains elevated among those at high risk such as persons in serodiscordant partnerships. Antiretrovirals taken by HIV-negative persons as pre-exposure prophylaxis (PrEP) has the potential to avert infections in individuals in serodiscordant partnerships. Evaluating the cost-effectiveness of implementing time-limited PrEP as a short-term bridge during the first six months of ART for the HIV-positive partner to prevent HIV transmission compared to increasing ART coverage is crucial to informing policy-makers considering PrEP implementation.