Conjugated equine estrogen and risk of benign proliferative breast disease: a randomized controlled trial.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 100, Issue 8, p.563-71 (2008)


2008, Aged, Biopsy, Breast Diseases, Breast Neoplasms, Center-Authored Paper, Confidence Intervals, Double-Blind Method, Estrogen Replacement Therapy, Estrogens, Conjugated (USP), Female, Follow-Up Studies, Humans, HYPERPLASIA, Kaplan-Meier Estimate, Middle Aged, Odds Ratio, Postmenopause, Precancerous Conditions, Prevention Center Core Facility, Proportional Hazards Models, Public Health Sciences Division, Research Design, Risk Assessment, Risk Factors, Shared Resources


Estrogens stimulate proliferation of breast epithelium and may therefore increase the risk of benign proliferative breast disease, a condition that is associated with increased risk of breast cancer. We tested the effect of conjugated equine estrogen (CEE) on risk of benign proliferative breast disease in the Women's Health Initiative (WHI) randomized controlled trial.