Confounding effects of hormone replacement therapy in protein biomarker studies.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 20, Issue 1, p.134-9 (2011)

Keywords:

2011, Blood Proteins, Early Detection of Cancer, Estrogens, Female, Hormone Replacement Therapy, Humans, Inhibins, mass spectrometry, Neoplasm Proteins, Ovarian Neoplasms, Postmenopause, Progesterone, Proteome, Public Health Sciences Division, Risk Factors, Somatomedins, Tumor Markers, Biological

Abstract:

We have recently investigated effects of hormone replacement therapy (HRT) on the serum proteome, and found a high proportion of proteins with altered levels associated with oral estrogen and/or estrogen plus progesterone treatment. Given this finding, we have investigated the extent to which exposure to HRT may have a confounding effect in the assessment of circulating proteins as cancer biomarkers.