The complete genome sequence of a Neanderthal from the Altai Mountains.

Publication Type:

Journal Article

Source:

Nature, Volume 505, Issue 7481, p.43-9 (2014)

Keywords:

2013, Africa, Animals, Caves, DNA Copy Number Variations, Female, Fossils, gene flow, Gene Frequency, GENOME, Heterozygote, Human Biology Division, Humans, Inbreeding, January 2014, Models, Genetic, Neanderthals, Phylogeny, Population Density, Siberia, Toe Phalanges

Abstract:

We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans.