Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.

Publication Type:

Journal Article

Source:

PloS one, Volume 4, Issue 9, p.e7122 (2009)

Keywords:

2009, Anti-HIV Agents, Cell-Free System, Center-Authored Paper, Cross-Sectional Studies, DNA, Viral, Female, Genetic Variation, Genitalia, Female, Genotype, HIV Infections, HIV-1, Humans, Likelihood Functions, Phylogeny, Public Health Sciences Division, RNA, Viral, Species Specificity

Abstract:

Compartmentalization of HIV-1 between the genital tract and blood was noted in half of 57 women included in 12 studies primarily using cell-free virus. To further understand differences between genital tract and blood viruses of women with chronic HIV-1 infection cell-free and cell-associated virus populations were sequenced from these tissues, reasoning that integrated viral DNA includes variants archived from earlier in infection, and provides a greater array of genotypes for comparisons.