Comparison of occupational exposure assessment methods in a case-control study of lead, genetic susceptibility and risk of adult brain tumours.

Publication Type:

Journal Article


Occupational and environmental medicine, Volume 68, Issue 1, p.4-9 (2011)


2011, Adult, Brain Neoplasms, Epidemiologic Methods, Genetic Predisposition to Disease, Genotype, Glioma, Humans, Lead, Meningioma, Occupational Diseases, Occupational Exposure, Polymorphism, Single Nucleotide, Porphobilinogen Synthase, Public Health Sciences Division


There is great interest in evaluating gene-environment interactions with chemical exposures, but exposure assessment poses a unique challenge in case-control studies. Expert assessment of detailed work history data is usually considered the best approach, but it is a laborious and time-consuming process. We set out to determine if a less intensive method of exposure assessment (a job exposure matrix (JEM)) would produce similar results to a previous analysis that found evidence of effect modification of the association between expert-assessed lead exposure and risk of brain tumours by a single nucleotide polymorphism in the ALAD gene (rs1800435).