Comparison of occupational exposure assessment methods in a case-control study of lead, genetic susceptibility and risk of adult brain tumours.

Publication Type:

Journal Article

Source:

Occupational and environmental medicine, Volume 68, Issue 1, p.4-9 (2011)

Keywords:

2011, Adult, Brain Neoplasms, Epidemiologic Methods, Genetic Predisposition to Disease, Genotype, Glioma, Humans, Lead, Meningioma, Occupational Diseases, Occupational Exposure, Polymorphism, Single Nucleotide, Porphobilinogen Synthase, Public Health Sciences Division

Abstract:

There is great interest in evaluating gene-environment interactions with chemical exposures, but exposure assessment poses a unique challenge in case-control studies. Expert assessment of detailed work history data is usually considered the best approach, but it is a laborious and time-consuming process. We set out to determine if a less intensive method of exposure assessment (a job exposure matrix (JEM)) would produce similar results to a previous analysis that found evidence of effect modification of the association between expert-assessed lead exposure and risk of brain tumours by a single nucleotide polymorphism in the ALAD gene (rs1800435).