Comparison of immunoscintigraphy, efficacy, and toxicity of conventional and pretargeted radioimmunotherapy in CD20-expressing human lymphoma xenografts.

Publication Type:

Journal Article

Authors:

Subbiah, Krishnan; Hamlin, Don K; Pagel, John M; Wilbur, D Scott; Meyer, Damon L; Axworthy, Don B; Mallett, Robert W; Theodore, Louis J; Stayton, Pat S; Press, Oliver W

Source:

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 44, Issue 3, p.437-45 (2003)

Keywords:

Animals, Antibodies, Monoclonal, Antigens, CD20, Avidin, Female, Humans, Immunoconjugates, Lymphoma, B-Cell, MICE, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Radioimmunotherapy, Streptavidin, TISSUE DISTRIBUTION, Transplantation, Heterologous, Tumor Cells, Cultured

Abstract:

Pretargeted radioimmunotherapy (RIT) using streptavidin (sAv)-conjugated antibodies before radiolabeled-biotin is a promising approach to improve absorbed dose ratios and achieve high durable remission rates with diminished systemic toxicity. This study compared the immunoscintigraphy, toxicity, and therapeutic efficacy of pretargeted RIT with conventional RIT using an anti-CD20 antibody.