Comparison of enzyme immunoassays for detection of antibodies to hepatitis D virus in serum.

Publication Type:

Journal Article

Source:

Clinical and vaccine immunology : CVI (2016)

Abstract:

Serology remains critical for diagnosing HDV infection, which affects 15 - 20 million people worldwide, but the literature on characterizing commercial enzyme immunoassays (EIAs) dates back to 15 years ago. We evaluated 2 commercial EIAs currently available for detecting anti-HDV antibodies. The DiaSorin assay demonstrated 100% sensitivity and specificity. Using modified cutoff, the Cusabio assay demonstrated sensitivity of 81.3% and specificity of 90.9%. Our data show that recently developed EIAs are reliable for anti-HDV antibody detection.