Comparative cell-mediated immunogenicity of DNA/DNA, DNA/adenovirus type 5 (Ad5), or Ad5/Ad5 HIV-1 clade B gag vaccine prime-boost regimens.

Publication Type:

Journal Article

Authors:

Asmuth, David M; Brown, Elizabeth L; DiNubile, Mark J; Sun, Xiao; del Rio, Carlos; Harro, Clayton; Keefer, Michael C; Kublin, James G; Dubey, Sheri A; Kierstead, Lisa S; Casimiro, Danilo R; Shiver, John W; Robertson, Michael N; Quirk, Erin K; Mehrotra, Devan V

Source:

The Journal of infectious diseases, Volume 201, Issue 1, p.132-41 (2010)

Keywords:

2010, Adenoviridae, Adjuvants, Immunologic, Adult, AIDS Vaccines, Center-Authored Paper, DNA, Viral, Female, Genes, gag, HIV-1, Humans, Immunization, Secondary, Male, Middle Aged, Placebos, Vaccine and Infectious Disease Division, Young Adult

Abstract:

We report composite results from the Merck phase I program of near-consensus clade B human immunodeficiency virus (HIV) type 1 gag vaccines.