Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.

Publication Type:

Journal Article

Source:

Clinical chemistry, Volume 55, Issue 8, p.1559-63 (2009)

Keywords:

2009, ADENOCARCINOMA, Adenoma, Adult, Aged, Aged, 80 and over, Cell Line, Tumor, Center-Authored Paper, Clinical Research Division, Colorectal Neoplasms, DNA, DNA Methylation, Early Detection of Cancer, Feces, Genomics Core Facility, Humans, Integrin alpha4, Middle Aged, Molecular Diagnostic Techniques, Polymerase Chain Reaction, Sensitivity and Specificity, Shared Resources, Tumor Markers, Biological

Abstract:

Aberrantly methylated genes are promising biomarkers for the detection of colon adenomas and colorectal cancers (CRCs). The optimal assay type and specific methylated genes for these assays remain to be determined.