Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.

Publication Type:

Journal Article

Source:

The Prostate, Volume 69, Issue 4, p.363-72 (2009)

Keywords:

2009, Adult, Aged, Case-Control Studies, Center-Authored Paper, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prostatic Neoplasms, Public Health Sciences Division, Research Trials Office Core Facility - Biostatistics Service, Risk Factors, ROC Curve, Shared Resources

Abstract:

A recent report suggests that the combination of five single-nucleotide polymorphisms (SNPs) at 8q24, 17q12, 17q24.3 and a family history of the disease may predict risk of prostate cancer. The present study tests the performance of these factors in prediction models for prostate cancer risk and prostate cancer-specific mortality.