Clinical relevance of molecular staging for melanoma: comparison of RT-PCR and immunohistochemistry staining in sentinel lymph nodes of patients with melanoma.

Publication Type:

Journal Article


Annals of surgery, Volume 231, Issue 6, p.795-803 (2000)


Adult, Aged, Female, Humans, Immunohistochemistry, Lymph Nodes, Male, MELANOMA, Middle Aged, Neoplasm Staging, Prospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Skin Neoplasms


To determine the clinical significance of a molecular assay based on the reverse transcriptase polymerase chain reaction (RT-PCR) for the presence of micrometastatic melanoma cells in sentinel lymph nodes (SLNs).