Circulating Tumor Cells and Response to Chemotherapy in Metastatic Breast Cancer: SWOG S0500.

Publication Type:

Journal Article

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2014)

Keywords:

2014, Clinical Research Division, June 2014, Public Health Sciences Division

Abstract:

Increased circulating tumor cells (CTCs; five or more CTCs per 7.5 mL of whole blood) are associated with poor prognosis in metastatic breast cancer (MBC). A randomized trial of patients with persistent increase in CTCs tested whether changing chemotherapy after one cycle of first-line chemotherapy would improve the primary outcome of overall survival (OS).