Cigarette smoking and colorectal cancer risk by molecularly defined subtypes.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 102, Issue 14, p.1012-22 (2010)


2010, Aged, Center-Authored Paper, Colorectal Neoplasms, Confidence Intervals, CpG Islands, DNA Methylation, DNA, Neoplasm, Epigenesis, Genetic, Female, Humans, Incidence, Iowa, Microsatellite Instability, Middle Aged, Mutation, Odds Ratio, PHENOTYPE, Proportional Hazards Models, Prospective Studies, Proto-Oncogene Proteins B-raf, Public Health Sciences Division, Registries, Risk Assessment, Risk Factors, Smoking


Cigarette smoking is an established risk factor for colorectal cancer. Because colorectal carcinogenesis is a heterogeneous process, we investigated whether cigarette smoking is differentially associated with molecularly defined subtypes of colorectal cancer.